Fri, Feb 25, 2011 1:05 pm EST Mocs @ Tigers Joker Marchant Stadium
| Sat, Feb 26, 2011 | 1:05 pm EST | Tigers | @ Blue Jays | Florida Auto Exchange Stadium |
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| Sun, Feb 27, 2011 | 1:05 pm EST | Blue Jays | @ Tigers | Joker Marchant Stadium | | |
| Mon, Feb 28, 2011 | 1:05 pm EST | Yankees | @ Tigers | Joker Marchant Stadium | | |
| Tue, Mar 01, 2011 | 1:05 pm EST | Tigers | @ Phillies | Bright House Networks Field |
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| Tue, Mar 01, 2011 | 1:05 pm EST | Blue Jays | @ Tigers | Joker Marchant Stadium |
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| Wed, Mar 02, 2011 | 1:05 pm EST | Astros | @ Tigers | Joker Marchant Stadium |
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| Thu, Mar 03, 2011 | 1:05 pm EST | Tigers | @ Braves | Champion Stadium |
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| Fri, Mar 04, 2011 | 1:05 pm EST | Orioles | @ Tigers | Joker Marchant Stadium |
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| Sat, Mar 05, 2011 | 1:05 pm EST | Tigers | @ Astros | Osceola County Stadium |
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| Sat, Mar 05, 2011 | 1:05 pm EST | Tigers | @ Blue Jays | Florida Auto Exchange Stadium |
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| Sun, Mar 06, 2011 | 1:05 pm EST | Phillies | @ Tigers | Joker Marchant Stadium |
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| Mon, Mar 07, 2011 | 1:10 pm EST | Tigers | @ Mets | Digital Domain Park |
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| Tue, Mar 08, 2011 | 1:05 pm EST | Marlins | @ Tigers | Joker Marchant Stadium |
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| Wed, Mar 09, 2011 | 1:05 pm EST | Phillies | @ Tigers | Joker Marchant Stadium |
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| Thu, Mar 10, 2011 | 7:05 pm EST | Tigers | @ Marlins | Roger Dean Stadium |
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| Fri, Mar 11, 2011 | 1:05 pm EST | Tigers | @ Cardinals | Roger Dean Stadium |
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| Sat, Mar 12, 2011 | 1:05 pm EST | Blue Jays | @ Tigers | Joker Marchant Stadium |
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| Sun, Mar 13, 2011 | 1:05 pm EDT | Astros | @ Tigers | Joker Marchant Stadium |
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| Sun, Mar 13, 2011 | 1:05 pm EDT | Tigers | @ Orioles | Ed Smith Stadium |
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| Mon, Mar 14, 2011 | 1:05 pm EDT | Tigers | @ Nationals | Space Coast Stadium |
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| Tue, Mar 15, 2011 | 1:05 pm EDT | Red Sox | @ Tigers | Joker Marchant Stadium |
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| Wed, Mar 16, 2011 | 1:05 pm EDT | Cardinals | @ Tigers | Joker Marchant Stadium | | |
| Thu, Mar 17, 2011 | 1:05 pm EDT | Twins | @ Tigers | Joker Marchant Stadium | | |
| Fri, Mar 18, 2011 | 1:05 pm EDT | Tigers | @ Red Sox | City of Palms Park | | |
| Sat, Mar 19, 2011 | 1:05 pm EDT | Braves | @ Tigers | Joker Marchant Stadium | | |
| Sun, Mar 20, 2011 | 1:05 pm EDT | Tigers | @ Nationals | Space Coast Stadium | | |
| Mon, Mar 21, 2011 | 1:05 pm EDT | Tigers | @ Astros | Osceola County Stadium | | |
| Tue, Mar 22, 2011 | 1:05 pm EDT | Mets | @ Tigers | Joker Marchant Stadium | | |
| Thu, Mar 24, 2011 | 6:05 pm EDT | Nationals | @ Tigers | Joker Marchant Stadium | | |
| Fri, Mar 25, 2011 | 6:05 pm EDT | Tigers | @ Braves | Champion Stadium | | |
| Sat, Mar 26, 2011 | 1:05 pm EDT | Phillies | @ Tigers | Joker Marchant Stadium | | |
| Sun, Mar 27, 2011 | 1:05 pm EDT | Tigers | @ Astros | Osceola County Stadium | | |
| Mon, Mar 28, 2011 | 1:05 pm EDT | Tigers | @ Orioles | Ed Smith Stadium | | |
| Tue, Mar 29, 2011 | 1:05 pm EDT | Tigers | @ Yankees | George M. Steinbrenner Field |
